Marie D. Wilson, 52, executive secretary of the Equal Employment Opportunity Commission since 1966, died of cancer Wednesday at Sibley Memorial Hospital.

She and her husband, Glen P. Wilson, came to Washington From Texas in 1955 to serve in the office of Sen. Lyndon B. Johnson. She was a secretary and he was a staff assistant.

Mrs. Wilson worked there for about a year. In 1959-60, she again worked for Sen. Johnson at the Democratic Policy Committee where she was involved in the passage of civil rights legislation.

In 1965, she was secretary to the directors of the inaugural committee for the inauguration of President Johnson. She then worked for real estate and public relations firms here until joining the Equal Employment Opportunity Commission.

Mrs. Wilson was born and educated in New York City. She moved to Austin, Texas, in 1952, where she worked for an architectural firm that handled work on the LBJ ranch.

She was a former member of the board of directors of the Texas State Society here.

In addition to her husband, of Washington she is survived by her stepmother, Gladys Cunneen, of St. Petersburg, Fla., and a stepbrother, William T. Northacker, of Rockville Center, N.Y.

The family suggests that expressions of sympathy be in the form of contributions to the American Cancer Society.