Anna L. Frank, 80, a Washington area resident for 45 years who was active as a hospital volunteer and in church organizations, died Tuesday at Holy Cross Hospital in Silver Spring after a stroke.

Born in Athens, Greece, Mrs. Frank came to the United States at the age of 12 to live with a sister in New York City. She also lived in Batavia, N.Y., before moving to the Washington area in 1935 with her husband, Samuel V. Frank. A Washington restaurateur for 23 years, he died in 1958.

Mrs. Frank was a volunteer at Holy Cross Hospital for more than 15 years. She was a member of Saint Sophia Green Orthodox Cathedral and its Philoptohos Society and Daughters of Penelope organization for 30 years.

Survivors include a son, William S. and four daughters, Bessie F. Bartlett, Helen F. Bartlett, Ehtel F. Changuris and Sophia F. Severino, all of Silver Spring; two other daughters, Mary F. Nasou of Kensington and Catherine McQueen of Dayton, Ohio, 20 grandchildren and 12 great-grandchildren.

The family suggests that expressions of sympathy be in the form of contributions in her name to the EAC building fund at Saint Sophia Greek Orthodox Cathedral in Washington.