Jose Antonio Mayobre, 66, former Venezuelan cabinet officer, ambassador to Washington and United Nations official, died of cancer Friday at George Washington University Hospital.

He came to Washington for treatment about a month ago from Caracas. With him was his wife, Esperanza Machedo.

Dr. Mayobre was named Venezuelan ambassador to Washington and the Organization of American States in November 1960. He resigned in May 1962 to become High Commissioner for Industrial Development in the United Nations.

In 1965, UN Secretary General U Thant appointed Dr. Mayobre as his special representative in the Dominican Republic after a revolt occurred there. At the time, Dr. Mayobre, a lawyer and economist, was executive secretary of the UN Commission for Latin America in Santiago, Chile.

He was born in Cumana, Venezuela. He received degrees in law and economics at the Central University of Caracas. He attended the London School of Economics.

Dr. Mayobre was an up-and-coming economist in Venezuela when he ran into trouble with the government of dictator Marcos Perez Jimenez and was sent into exile. He returned to Venezuela in 1958 when the Perez Jimenez regime was overthrown. He later was appointed minister of finance.

After his service with the UN, he rejoined the Venezuelan cabinet as minister of energy in 1967. From 1969 until his death, he was in private enterprise and was an advisor to the Venezuelan government in Caracas.

In addition to his wife, survivors include two sons, Eduardo of Carderock Springs, Md. and Jose Antonio Jr., of Paris.