Donald R. Weidman, 43, a retired program analyst and evaluator in the office of Management and Budget, died of cancer Friday at Georgetown University Hospital. He lived in Oxon Hill.

Mr. Weidman had been with the Management and Budget Office for several years before retiring earlier this year because of ill health.

He was born in Washington and grew up in Kansas City, Kan., where he graduated from Rockhurst College in 1958. He earned a doctor's degree in mathmematics from the University of Notre Dame in 1964.

Mr. Weidman taught mathematics at Boston College in Massachusetts for several years, and then became a systems analyst at the Naval Weapons laboratory in Dahlgren, Va., now known as the Naval Surface Weapons Center. He was on the senior research staff of the Urban Institute here before joining the Management and Budget Office.

He was a member of St. Mary's Catholic Church in Clinton and was active in the Marriage Encounter program.

He is survived by his wife, the former Janice Ferro, and four children, Susan Marie, Gregory Joseph, Wendy Theresa and Jennifer Catherine, all of Oxon Hill; his father, Harold E., and a brother, Gerald A., both of Kansas City, Kan., and another brother, the Rev. Harold Weiman, S.J., of Denver.

The family suggests that expressions of sympathy be in the form of contributions to Marriage Encounter, in care of the Rev. Camillus Gott, St. Bonaventure Friary, in Washington; or the Vincent T. Lombardi Cancer Research Center at Georgetown University Hospital.