Eleanor F. Reilly, 74, who was active in a number of educational and civic organizations here, died of cancer Friday at the Washington Hospital Center. She lived in Washington.

She was the wife of Gerard D. Reilly, retired chief judge of the D.C. Court of Appeals.

Mrs. Reilly was born in Boston. She attended public schools in Brookline, Mass., and Miss Lee's School in Boston and graduated in 1929 from Connecticut College for Women. She came to Washington with her family in 1933.

Prior to her marriage in 1939. Mrs. Reilly worked on the research staff of the International Labor Office and the legislative staff of the League of Woman Voters.

She was cofounder of the Georgetown Nursery School in the 1940s. She had served as secretary of the board of directors of the Georgetown Children's House and of Family and Child Services, had been secretary of the Cleveland Park Book Club and had been president of the Kingsbury Remedial Education Center. She had been a member of the Sulgrave Club.

In addition to her husband, of Washington, she is survived by a son, John Fahey Reilly of Washington; a daughter, Mrs. Richard T. Heffern of Guayaquil, Ecuador: a sister, Margaret Fahey Rudolph of Boston, and three grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the Needy Sick Fund of the Washington Hospital Center.