Anne H. Wright, 78, an analytical biologist at the Arthritis and Metabolical Disease Institute of the National Institutes of Health in Bethesda, died of cancer Monday at Georgetown University Hospital.

Mrs. Wright was born in Rotterdam, The Netherlands. She and her family came to the United States about 1912 and she grew up in Rochester, N.Y. She graduated from Middlebury College in 1930.

Following her marriage to Dr. Charles L. Wright, a biochemist, the couple lived in Vermont and Michigan. They moved to the Washington area in 1939.

Mrs. Wright began her career at NIH in 1943.Following her retirement in 1972, she moved from Bethesda to St. Petersburg, Fla., where she maintained a home until her death. She was stricken while visiting family here.

Her husband died in 1963.

Survivors include one son, Neil, of Beaver Creek, Md.; two daughters, Barbara Cabaniss of Hamilton, Va., and Helene Wheeler of Durwood, Md.; two brothers, John Van Kesteren of Onancock, Va., and Henry Van Kesteren of St. Petersburg, Fla.; two sisters, Betty Viguie of Redwood City, Calif., and Mary Ferguson of Puerto Rico, and five grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the Bethesda-Chevy Chase Rescue Squad, 5020 Battery Lane, Bethesda.