Mary E. Ferguson, a senior at the College of William & Mary in Williamsburg, Va., and a resident of Northern Virginia for much of her life, died at Williamsburg Community Hospital on Saturday of injuries sustained earlier that day when she was struck by a vehicle near there.

Virginia State Police said Miss Ferguson was struck near Rtes. 60 and 658 as she was crossing the road.

Miss Ferguson was studying biology at William & Mary and was an intern at the Virginia Institute of Marine Science at Glocester, Va., in the summer of 1979. She also had been a disc jockey on the college radio station, WCWM, for two years.

A native of Alexandria, Miss Fergusion grew up in Annandale, in Taiwan, where her father was stationed on government business for four years, in Williamsburg, in Annandale again, and in Reston, her home at the time of her death. She was a 1977 graduate of Bishop Dennis J. O'Connell High School and was a finalist in the Merit Scholarship competition in her senior year.

Her other activities included working as a free-lance illustrator for publications of George Mason University. She was a member of the parish of St. John Neumann Catholic Church.

Survivors include her mother, Aileen Ferguson of Reston, her father, James E. Ferguson of Arlington, and two brothers, Air Force M/Sgt. James E. Jr., who is stationed at Goldsboro, N.C., and Andrew M. of Williamsburg.

The family suggests that expressions of sympathy be in the form of contribution to a charity of one's choice.