William C. Fisher, 74, the director of the office of the Small Business Administration for 14 years before retiring in 1967, died of cancer Friday in his home in Fort Pierce, Fla.

Mr. Fisher began his government career in Washington with the Agriculture Department in 1932. He joined the Federal Home Loan Bank Board in 1936 and was director of personnel for the next two years.

In 1939, he transferred to the Reconstruction Finance Corporation as personnel director there. He worked for the RFC until joining the Small Business Administration in 1953.

Mr. Fisher was a native of Washington and lived in Chevy Chase, Arlington, and then Falls Church before moving to Fort Pierce, Fla., about three years ago. He was a 1932 graduate of the Virginia Polytechnic Institute where he won letters, in football, baseball, basketball, boxing and wrestling.

During World War II, he served with the Army as a transportation officer on the staff of Supreme Headquarters, Allied Expeditionary Force. He attained the rank of lieutenant colonel.

Survivors include his wife, Jean Of Fort Pierce; two daughters, Joanne Arneson of Columbia and Carlie McBride of Jensen Beach, Fla.; two brothers, Joseph A. Jr. of Arlington and Eugene T. of Fairfax, and four grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the American Cancer Society.