Dr. Hugh Wilson Josephs, 88, a pioneer in the study of children's blood diseases and an associate professor of pediatrics at the John Hopkins University School of Medicine, died of cardiopulmonary arrest Sunday at John Hopkins University Hospital.

Dr. Josephs was born in New Orleans and graduated from Harvard University. He earned a medical degree from the Johns Hopkins school of pediatric medicine in 1919 and served both as an intern and resident physician there.

Except for a year as a National Research Fellow in chemistry at the University of Chicago, where he met his wife of 54 years, Dr. Charlotte McCarthy, he remained in the pediatrics department at Johns Hopkins until his retirement in 1957. After retiring, he continued to participate in the department over the years.

The author of numerous publications in his field, Dr. Josephs was particularly known for his clinical studies on spontaneous hypoglycemia in children and anemia of infancy and childhood, particularly as related to iron metabolism and increased hemolysis, and for his studies on vitamin A, especially regarding hypervitaminosis, a disorder caused by excessive dosage.

Dr. Josephs, who lived in Ruxton, Md., was a member of the American Pediatric Society, the Society of Clinical Investigation, the Society of Pediatric Research, the Amercian Academy of Pediatrics and the Southern Medical Association.

Besides his wife, survivors include a sister, Mrs. Laurence Fowler of Baltimore.