Lucile Newton Fisher, 74, a retired real estate sales representative who was active in real estate groups and in civic and community affairs, died of cancer yesterday at her Washington home.

Mrs. Fisher, who specialized in residential sales, was employed by the W.C. and A.N. Miller Development Co. in Maryland from 1952 until her retirement earlier this year for reasons of health. In 1977, she was elected first Realtor Associate of the Year by the Million Dollar Sales Club of the Washington Board of Realtors, of which she was a life member.

She served as vice president of the D.C.-Montgomery County Chapter of the Women's Council of Realtors and was a member of the Washington and Montgomery County Boards of Realtors and the National Association of Realtors.

Mrs. Fisher was a past president of the Spring Valley-Wesley Heights Arts Club. She served as a coordinator for National Symphony fund raising campaigns and was a sponsor of the American Opera Scholarship Society. She was active in the Twentieth Century Club and was a life member of the American Overseas Association.

She was born in Middleton, Ohio, and attended Marshall University in West Virginia and the University of Cincinnati. She was a social worker in Cincinnati and a labor relations specialist for the Labor Department in Cleveland before moving to this area.

During World War II, Mrs. Fisher was a volunteer with the Civilian War Relief program of the American Red Cross in Europe. She then served as a delegate of the League of Red Cross Societies for Germany and Austria until 1950, when she married Robert L. Fisher, a retired United Nations official and Army Reserve colonel.

Mrs. Fisher is survived by her husband.

It is suggested that expressions of sympathy be in the form of contributions to the American Cancer Society, the American Red Cross or a charity of one's choice.