Andrew A. Simms Sr., 54, a manpower development specialist at the Department of Labor and a lifelong resident of the Washington area, died Monday at the Washington Hospital Center of complications from a brain tumor.

Mr. Simms was born in Washington and graduated from Armstrong High School here. He served in the Army in World War II and then began his civilian career with the government.

He was a procurement officer with the Department of the Army and worked at Walter Reed Army Medical Center, Cameron Station in Arlington and at Fort Myer. He later as promoted to contracting officer.

In 1970, Mr. Simms transferred to the Labor Department, where he also was a contracting official. He became a manpower development specialist two years ago. At the time of his death, he had completed 34 years of government service.

Mr. Simms, who lived in Upper Marlboro, was a member of Local 12 of the American Federation of Government Employees.

Survivors include his wife, Gwendolyn, of Upper Marlboro; one son, Andrew A. Jr., of Washington; two daughters, Antionette Roland of Washington, and Avella Ramsey of Uniontown, Pa.; a step-daughter, Adrienne Baron of Upper Marlboro; a sister, Jewel Johnson, and three brothers, Oscar, Richard Sr., and Raphael Simms, all of Washington, and six grandchildren.