Sonia Sheftell, 82, who for 36 years owned and operated the Regis Room, a millinery store on Connecticut Avenue, was found dead Tuesday at her home in Northwest Washington.

The D.C. medical examiner's office said she died of hypertension and cardiovascular disease.

Mrs. Sheftell opened the Regis Room in 1944 and continued to run the store until she retired earlier this year. Among her clients were such well-known persons as Alice Rossevelt Longworth and Mrs. Dwight D. Eisenhower. She was a former chairman of the Connecticut Avenue Business Association.

A native of Russia, Mrs. Sheftell came to the United States in 1921 and settled in Washington. She had been a medical student in Russia and after her arrival here she joined the nurse's training program at the old Episcopal Eye, Ear, Nose and Throat Hospital. She earned her registered nurse's degree and was on the hospital's staff until her marriage in 1924 to Harry Sheftell, a Washington photographer. Mr. Sheftell died in 1941.

Mrs. Sheftell was a member of Hadassah and a supporter of the Hebrew Home for the Aged, among other organizations.

Survivors include two sons, Alex, of Potomac, and David J., of Bethesda, and four grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to a charity of one's choice.