Regina C. Kane, 66, a resident of Silver Spring since 1969 and a member of the parish of the Christ the King Catholic Church there, died of cancer Monday at Georgetown University Hospital.

Mrs. Kane was born in Sugar Notch, Pa. She graduated from the Empire Beauty School in Wilkes-Barre, Pa., and worked for a chain of beauty shops in that city. She later returned to the Empire school as a district supervisor.

In 1945, she married Joseph G. Kane and the couple settled in Elmont, N.Y., where Mr. Kane was an official of the Bakery, Confectionary and Tobacco Workers Union (AFL-CIO). In 1969, when he was named executive vice president of the union in Washington, the family moved to Silver Spring. Mr. Kane died in 1979.

Mrs. Kane's survivors include two daughters, Barbara Queenan of West Babylon, N.Y., and Marylin Kane Jansen of Silver Spring; two sons, Robert and Brian, also of Silver Spring; three sisters, Helen Fedock of Elmhurst, N.Y., Celia Stemrich of Allentown, Pa., and Louise McGowan of Phoenixvile, Pa.; one brother, Leonard Brodginski of Flushing, N.Y., and three grandchildren.

The family suggess that expressions of sympathy be in the form of contributions to the Christ the King Church Building Fund. 2300 East-West Hwy., Silver Spring, 20910.