Mary Aiello House, 80, a former employe of the D.C. government who later was active in medical and service groups, died of cancer Sunday at the Washington Hospital Center.

Mrs. House, who was born in Johnsonburg, Pa., came to Washington in 1924 and became the secretary of Superintendent Ernest W. Brown of the Metropitan Police Department. She later was the secretary to two D.C. corporation counsels, Elwood Seal and Robert E. Lynch. While working, she was graduated from the Strayer Business College.

In 1941, she married Dr. Hugh O. House, a Washington ear, nose and throat specialist. In 1942, she resigned from the D.C. government.

From 1941 until her death, Mrs. House was the treasurer of the Metropolitan Police Boys Club Auxiliary. She also was a member and past president of the D.C. Medical Society Auxiliary and a member of the Southern Medical Society Auxiliary and the George Washington University Hospital Auxiliary.

Her husband died last week.

Survivors include two children, Dr. Homer C., of Baltimore, and Toni House Wilson, of Chevy Chase; one brother, Umbert S. Aiello, of Silver Spring; one sister, Eva A. Buckingham, of takoma Park, and four grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the Metropolitan Police Boys and Girls Club, 1700 Rhode Island Ave., NE, Washington, D.C.