Lewis H. Lederer, 75, a retired official of the old U.S. Information Agency and a musician and painter, died of cancer Tuesday at Fairfax Hospital. He lived in Annandale.

Mr. Lederer was born in Louisville, Ky., and grew up in Cincinnati. He attended the Art Academy of Cincinnati, the Cincinnati Collge of Music and the Ohio Mechanics Institute. In the 1920s and 1930s, he was in the advertising business in Cincinnati. He also played the piano for a number of dance bands.

During World War II, he served in the Army as a public information officer. He later started a public relations and advertising firm in Los Angeles. During the Korean conflict, he was recalled to active duty in the Army and served in Korea. He then was stationed in Washington, where he was assigned to the Armed Forces radio and television networks. He left the service with the rank of lieutenant colonel.

In 1955, Mr. Lederer joined the USIA, now the International Communication Agency. He served in Indonesia, Iran, in Washington, where he was assigned to the Voice of America, and in Australia, where he was director of the U.S. Information Service in that country and public affairs officer for the U.S. Embassy. He retired from the government in 1969.

Mr. Lederer had a number of shows of his abstract paintings in Washington and elsewhere. During his years abroad with the USIA, he played the piano on local radio stations. He was a president of the Metropolitan Organ Society and of the Fairfax County branch of the Hammond Organ Society.

Survivirs include his wife, Marjorie, of Annandale; two children, Leon, an ICA officer stationed in Rio de Janeiro, Brazil, and Ellyn Rosen of Alexandria; one brother, Dr. Henry Lederer of Chevy Chase, and five grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the American Cancer Society.