The Rev. Ann Sandefer, 68, the minister of the United Center of Christianity in Washington from 1947 until her retirement in 1969 and a former president of the Unity Ministers' Association, died of cancer Monday at her home in Arlington.

Mrs. Sandefer, who was born in Washington, graduated from the old Business High School and attended George Washington and American universities. In the 1930s, she was a secretary at Peoples Drug Stores and The Washington Post. She also began her studies of Unity teachings through correspondence courses and by attending Unity gatherings.

In 1943, she went to Kansas City, Mo., to study at the Unity School of Christianity. In 1946, she returned to this area and the following year was named minister of the Unity Center of Christianity. She was a founder of Unity of Baltimore and helped found Unity of Fairfax. s

In 1951, Mrs. Sandefer was ordained. In 1957, she was elected president of the Eastern Conference of Unity Ministers and in 1960 was elected a director of the Unity Ministers' Association. She was president of that organization in 1964.

Mrs. Sandefer was a Girl Scout leader from 1957 to 1963. She also worked with the American Metaphysical Society and was named to its board of directors. Her hobbies included china painting.

Survivors include her husband J. Glynn Sandefer of Arlington; two daughters, Diane S. Stark of Hyattsville, and Marth Sandefer of Fairfax; one brother, the Rev. George T. Eppley of Oceanside, Calif., and two granddaughters.