Ann Brown Blandford, 69, a volunteer with the Alexandria chapter of the American Red Cross and a resident of the Washington area since 1961, died of cancer Wednesday at her home in Alexandria.

Mrs. Blandford, who was born in Blackburg, Va., graduated from the University of North Carolina at Greensboro in 1932. She then went back to Blacksburg and for a year was a physical education instructor at Virginia Polytechnic Institute.

In 1933, she married an Army officer, William O. Blandford, now a retired brigadier general. Before World War II, the Blandfords lived at various military posts in the United States and in the Panama Canal Zone. After the war, their overseas postings included West Germany and Taiwan.

Mrs. Blandford was a Red Cross volunteer for most of her life. Besides her work with the Alexandria chapter, she was international volunteer with the eastern region of the Red Cross.

She also was a member of the Daughters of the American Revolution and the Colonial Dames.

In addition to her husband, of Alexandria, survivors include two sons, Robert R., of Alexandria, and William J., of Racine, Wis.; two daughters, Barbara Ann Helm of Coronado, Calif., and Margaret L. Emery of Reston; one brother, Willard Brown of Blacksburg, and five grandchildren.

The family suggests that expressions of sympathy be in the form of contributions to the Alexandria chapter of the American Red Cross.