Eleanor Elizabeth Omohundro, 58, a retired administrative assistant with the Federal Reserve Board and a former member of the Potomac Chrysanthemum Society, died of cancer Tuesday at her home in Silver Spring.

Miss Omohundro was born in Lansdowne, Pa., and grew up there and in Washington. She graduated from Roosevelt High School and in 1944 earned a bachelor's degree from Mary Washington College in Fredericksburg, Va.

After college, she returned to Washington and went to work in the trust department of the Urban Trust Bank.She also was active in the American Institute of Banking, from which she received a gold medal for her success in professional courses offered by the institute. She held a number of offices in its local chapter.

About 1950, Miss Omohundro joined the Federal Reserve Board. At the time of her retirement last December after 30 years of service, she was an administrative assistant in the division of Federal Reserve bank operations.

As a member of the Potomac Chrysanthemum Society, Miss Omohundro won a number of first-place prizes in flower shows. She also was an amateur pianist and enjoyed playing for her friends. She was a member of the St. Luke Lutheran Church in Silver Spring.

Survivors include her parents, Edgar H. and Clara E. Omohundro of Arlington.

The family suggests that expressions of sympathy be in the form of contributions to the Holy Cross Hospice, c/o Holy Cross Hospital, 1500 Forest Glen Rd., Silver Spring, Md.