Howard Saylor Hufford, 60, a retired employe of the Central Intelligence Agency and an Army veteran of World War II, died Monday at Jefferson Memorial Hospital in Charles Town, W.VA., of a general anaphylactic reaction to a bee sting.

Mr. Hufford, who earned a master's degree in Russian studies from the University of Pennsylvania, joined the CIA in 1950. He was assigned to Nicosia, Cyprus, Frankfurt, Germany, and CIA headquarters in Langley before retiring in 1972.

In World War II, he was a captain in the Army in Europe.

A native Washingtonian, Mr. Hufford spent part of his childhood in China, where his father was an Army surgeon in the 1920s. He graduated from Mercersburg Academy and Lafayette College, both in Pennsylvania, and studied the Russian language at Middlebury College in Vermont.

He lived in Arlington until 1978, when he moved to Charles Town.

Mr. Hufford was a volunteer with Meals on Wheels programs in Arlington and Charles Town and a member of Rock Spring Congregational Church in Arlington.

Survivors include his wife, the former Caroline Muhlenberg, of Charles Town; five sons, Henry M., of Tucson, Frederick H., of Arlington, Nicholas S., of Betterton, Md., and Stephen S. and Mark T., both of McLean; his mother, Mary Saylor Hufford of Reading, Pa.; and a sister, Clara L. Hufford of Huntingdon Valley, Pa.

The family suggests that expressions of sympathy be in the form of contributions to Meals on Wheels of Charles Town, Jefferson County, W.Va., or to a charity of one's choice.