Isadore (Izzy) Kessler, 59, an independent certified public accountant and a longtime area resident, died of cancer Wednesday at Holy Cross Hospital in Silver Spring.

Mr. Kessler, who lived in Silver Spring, was born in Baltimore and moved to Washington at an early age. He was a graduate of the old Central High School and Benjamin Franklin University.

After serving in the Navy during World War II, he worked in several local businesses before joining the Washington accounting firm of Smulkin, Barsky, Hoffman and Denton, now part of Fox and Company, as a certified public accountant in 1960. He remained with the firm until about 1970, when he began a private practice in certified public accounting.

Mr. Kessler was a member of the D.C. and the American Institute of Certified Public Accountants and the Association of Practicing Certified Public Accountants. He was a member of the Jewish War Veterans Post 567, B'nai B'rith, and the Washington Hebrew Congregation and was a member of the steering committee of the Universtity of Maryland, College Park Parents Association. He was also active with the Montgomery County Concerned Citizens Against Drug Use and Abuse.

Survivors include his wife of 26 years, Linda Mae; two daughters, Geri Lynn and Karen Gail, and a son, Richard Alan, all of Silver Spring; two brothers, Julius J. of Silver Spring and Herman S. of Potomac, and a sister, Rena K. Franklin of Silver Spring.

The family suggests that expressions of sympathy be in the form of contributions to the American Cancer Society, or to the Montgomery Hospice Society.