Gloria Grahame, 51, a sultry, honey-blond actress who often portrayed "the other woman" in movies of the 1940s and 1950s, and won the Academy Award for best supporting actress for her role in "The Bad and the Beautiful" in 1952, died Monday in a hospital in New York City. She had cancer.

She is best remembered for her appearance in "It's a Wonderful Life," a sentimental comedy directed by Frank Capra. In addition to her Oscar for "The Bad and the Beautiful," a melodrama about Hollywood, she was nominated for Academy Awards for her supporting roles in the films "Crossfire" and "The Greatest Show on Earth."

Miss Grahame's other picture credits include "Blonde Fever," "Without Love," "The Good Die Young," "Merton of the Movies," "The Big Heat," "The Man Who Never Was," "Sudden Fear," "Macao," "It Happened in Brooklyn," and "Song of the Thin Man."

She is also well remembered for singing the role of Ado Annie in the film version of the musical comedy "Oklahoma!"

In 1955, she left her film career to have a child and did not return to the screen for 15 years. In 1970, she costarred in "What Are We Going to Do About Skipper?" in which she played the mother of a vicious young killer.

She was married and divorced four times. Her husbands included actor Stanley Clements, film director Nicholas Ray, television producer Cy Howard and Anthony Ray, stepson of her second husband.

Miss Grahame's survivors include her mother and four children.