Elizabeth Cardozo Barker, 80, a former president of the D.C. cosmetology board and a former owner of the Cardozo Sisters beauty shop, died Tuesday at Cape Cod Community Hospital in Hyannis, Mass., following a heart attack.

Mrs. Barker, who lived in Washington until moving to Osterville, Mass., when she retired three years ago, opened the Cardozo Sisters beauty shop in 1928. Her partners in the venture were three of her sisters, Margaret Holmes, Catherine Lewis and Emmeta Hurley. When they had run the business for 50 years, the sisters sold it and retired.

Mrs. Barker was appointed the D.C. cosmetology board in 1963. She was named president in 1967 and held that post until she retired in 1970.

Mrs. Barker, who was born in Washington, was a granddaughter of Francis L. Cardozo, the black educator for whom Cardozo High School is named.

Her marriage to Julian Nicholas ended in divorce. Her second husband, Beltran Barker, died in 1979.

Survivors include two sons, Julian Nicholas of Washington, and Frank Cardozo Nicholas of Marstons Mills, Mass.; her four sisters, Mrs. Holmes of Hyannisport, Mass., Mrs. Hurley of Columbia, Md., Mrs. Lewis of Washington, and Frances Payne of Columbia; three grandchildren, and one great-grandchild.