Mildred Ann Gill Mersereau, 74, a retired project director with the D.C. Department of Health and Human Services who was active in programs for Spanish-speaking persons, died Aug. 30 at Sibley Memorial Hospital. She had amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

Mrs. Mersereau, who lived in Washington for 35 years, joined Health and Human Services in 1971 when she went to work for the Area A Mental Health Center. There she helped start Project Puente, a program of English-language classes for domestic workers.

She also was a principal sponsor of the Spanish Senior Citizens Center in Washington and the Educational Organization for Latin Americans and a founding member of Cooperativa Latina.

She served on the board of the Washington YWCA, where she helped develop a bilingual training program for office workers. She retired from the D.C. government in 1978. From 1961 to 1971, she worked for the League of Women Voters.

Last May, she received a meritorious service citation from Mayor Marion Barry Jr.

Mrs. Mersereau was born in New York City. She graduated from Radcliffe College. She was the author of several children's books.

Her marriage to James F. Mersereau ended in divorce.

Survivors include a son, James Gill Mersereau of Chevy Chase; two daughters, Anne Chenoweth Byers of Larchmont, N.Y., and Susan Barret Aiwohi of Annandale; a sister, Susan Gill Dunn of New Canaan, Conn., and five grandchildren.