Dr. Harrison H. Leffler, 92, a Washington pathologist for 45 years until his retirement in 1967, died of cardiorespiratory failure Dec. 22 at the Brooke Grove nursing home in Olney.

Dr. Leffler was born in St. Augustine, Fla., and reared in Vermont. He graduated from the University of Vermont and also earned his medical degree there. He served in the Navy in Washington during World War I and remained here after the war.

He established a private practice here and also served on the staff of the old Gallagher Hospital and later on the staff of Providence Hospital. He worked with Professional Laboratories at the time of his retirement.

Dr. Leffler was a founding fellow of the American College of Pathologists and a member of the American Society of Clinical Pathology, the Washington Society of Pathologists and the Association of the Clinical Scientists.

In 1967, he moved from Washington to Rossmoor Leisure World in Silver Spring, where he was active in the Interfaith Chapel, the Masons and the Kiwanis Club.

Survivors include his wife, Nora T., of the Brooke Grove facility; three sons, Harrison H. Jr. and Warren K., both of Rockville, and John P. of Columbia, Md.; eight grandchildren and two great-grandchildren.