Leonard Rose, 66, a leading cello soloist and master teacher, died of leukemia Nov. 16 at White Plains Hospital in White Plains, N.Y.

A former first cellist with the New York Philharmonic, Mr. Rose taught many of the world's most prominent cellists, including Yo-Yo Ma and Lynn Harrell and several cellists in the nation's leading symphony orchestras.

Mr. Rose was born in Washington and studied at the Curtis Institute of Music in Philadelphia, graduating in 1938 at age 20. The same year, he married his first wife, Minnie, who died of leukemia in 1964, and started his career as assistant first cellist with the NBC Symphony Orchestra.

Mr. Rose went to the Cleveland Symphony in 1939 and remained as first cellist until 1943, when he joined the New York Philharmonic. He was named first cellist the next year, a position he retained until 1951, when he left to pursue a solo career. He had taught at the Juilliard School in New York since 1947.

In 1960, violinist Isaac Stern founded a trio with pianist Eugene Istomin and Mr. Rose. The group, one of the most sought-after ensembles in the United States, recorded the complete trios of Beethoven, Brahms, and Schubert and made television films of their performances.

Violinist Pinchas Zuckerman, Mr. Rose and Stern toured as a string trio in recent years.

As a soloist, Mr. Rose toured worldwide. He made an annual coast-to-coast tour of the United States, and he had been scheduled to perform as a soloist with the New York Philharmonic during the current season, according to Sheldon Gold, his agent.

"We have lost not only a great artist, but a friend and someone whose impact in the profession is going to be felt for many years," Gold said.

Mr. Rose, who lived in Hastings-on-Hudson, N.Y., is survived by his second wife, Xenia; and two children by his first marriage, Barbara Schirota and Arthur, and three grandchildren.