Duffy Daugherty, 72, who guided Michigan State's football program to national prominence and two Big Ten Conference titles in 19 years as head coach, died of kidney failure and heart ailments yesterday at a hospital in Santa Barbara, Calif.

Known for his pixyish Irish wit and jovial nature, Mr. Daugherty set the standard for Michigan State coaches, compiling a 109-69-5 record and leading eight teams to Top 20 finishes between 1954 and 1972.

His career was highlighted by the powerhouse teams of the 1965 and 1966 seasons, which had a combined 19-1-1 record with stars such as Gene Washington, Bubba Smith and Clint Jones. Michigan State won the national championship in 1965 and Big Ten titles in 1965 and 1966.

Many fans will remember Mr. Daugherty as the coach who led the No. 2 Spartans to a frustrating 10-10 tie with top-ranked Notre Dame in the 1966 "Game of the Century."

Mr. Daugherty's teams played in two Rose Bowl games, beating UCLA 17-14 in 1956, then losing to UCLA 14-12 in 1966.

After leaving the coaching position, Mr. Daugherty remained at Michigan State as a special assistant to the vice president for development. He retired Sept. 20, 1974, and the following year he and his family moved to Santa Barbara.

Born Sept. 8, 1915, in Emeigh, Pa., Mr. Daugherty grew up in Barnesboro, Pa. He graduated from high school when he was 15, then worked in coal mines for four years before entering Syracuse University where he played guard on the football team for three seasons. He broke his neck during a 1938 game against Penn State, but returned to become a captain of the 1939 Syracuse team.

After college he joined the Army and served in World War II. He was awarded a Bronze Star and was discharged as a major.

Mr. Daugherty was a line coach at Syracuse in 1946 and went to Michigan State as an assistant coach in 1947. There he directed the lines that earned the nickname "Duffy's Toughies" while the team went 54-9-2.

In recent years, Mr. Daugherty conducted coaching clinics with former Oklahoma football coach Bud Wilkinson.

Survivors include his wife, Frances; one son, Danny; one daughter, Dree; one sister, Jean Daugherty; and his mother, Elizabeth Daugherty.