Two persons have died in separate automobile accidents in the metropolitan area, police reported yesterday, and two area residents were killed in accidents in Richmond and North Carolina.

In the District, a 22-year-old Washington man was killed about 3 a.m. yesterday when the car he was driving went out of control in the 7300 block of Blair Road NW and struck a retaining wall, D.C. police said. They said the man was thrown from his car and the vehicle then fell on top of the man.

Detective Patrick Urban identified the victim as Anthony F. Roche of 7520 Eastern Ave. NW.

Urban said no other cars or people were involved and that a preliminary report indicated speed was a factor in the wreck. The man not wearing a seat belt, Urban said. "He basically lost control of his car," the detective said.

In Montgomery County, police said Miriam Rita Jean, 18, of 1330 Mimosa La., Silver Spring, was killed late Wednesday night when the car she was riding in was struck by another vehicle at the entrance to Glenmont Shopping Center at Randolph Road and Glenmont Circle.

Police said Jean, a back seat passenger in a car occupied by several other persons, was thrown through the rear window when the vehicle spun around after colliding with the second car.

Police said the car Jean was riding in was trying to turn left into the shopping center from Randolph Road when it was struck.

Police said six other persons were injured, but details of their conditions were not available.

North Carolina authorities reported that Robert Lee Sauls, 29, of Temple Hills, Md., was killed at 10 a.m. Thursday on a rural road in Greene County, seven miles west of Snow Hill, N.C. Sauls was thrown from his vehicle after it left the road at high speed, troopers said.

Virginia state police reported Francis Dempsey Thompson Jr., 22, of Bryans Road, Md., died at 11:46 a.m. Thursday on the way to the Medical College of Virginia hospital in Richmond. Thompson was driving a 1984 Toyota pickup east on Virginia Rte. 207 in Caroline County when he swerved to pass a vehicle and lost control of his truck, police said. The truck overturned several times in the median, causing the driver to be ejected. Police said Thompson was not wearing a seat belt.