Sterling Tucker, the District's anti-drug czar, resigned from his post yesterday to enter the campaign for D.C. delegate to Congress.

Tucker said last night that he delivered his resignation to Mayor Marion Barry "several weeks ago" and that it was effective at midnight last night.

He said the date of his departure has "nothing to do with" the scheduled start today of the mayor's trial on drug-related charges.

A former chairman of the D.C. Council, Tucker said he had wanted to make certain that his plans for anti-drug programs in the District were in order before leaving the post, to which he was appointed by the mayor about a year ago.

A formal announcement of his candidacy in the crowded Democratic primary will be made Wednesday, he said.

The D.C. delegate's seat has been held for 19 years by Walter E. Fauntroy, who is running for mayor.

Tucker said he is leaving the drug post, which he said he had accepted as a temporary position, with "mixed feelings" but with satisfaction about what has been accomplished during his tenure.

Also seeking the Democratic nomination are D.C. Council member Betty Ann Kane; former Equal Employment Opportunity Commission chairman Eleanor Holmes Norton; Joseph Yeldell, former director of the D.C. Office of Emergency Preparedness; former school board member Barbara Lett Simmons; Nation of Islam legal adviser George X. Cure, and Donald Temple, former legal adviser to the House District Committee.