George Miller, 61, a longtime stand-up comedian who appeared on close friend David Letterman's late-night talk shows more than any other comic, died March 1 at a hospital here.

Mr. Miller, who had leukemia, died as a result of a blood clot on his brain.

In all, Mr. Miller appeared on NBC's "Late Night With David Letterman" and CBS' "Late Show With David Letterman" 56 times in two decades -- a caustic but clean monologist needling Letterman while showcasing his latest lines and laments, usually about the stuff of everyday life.

"George was my oldest friend, and one of the funniest people I ever knew," Letterman said in a statement released through his publicist. "We are all very sad that he is gone."

The two met in Los Angeles in the early 1970s, when both were emerging comics. They lived in the same apartment building across the street from the Comedy Store on Sunset Boulevard and were part of a class of young comedians that included Jimmie Walker, Jay Leno and later Robin Williams and Garry Shandling.

Unlike most stand-ups today, said Tom Dreesen, who was also part of the group, Mr. Miller "was just content to be a stand-up comedian. He truly just wanted to write funny things and say funny things."

The goal was to get a spot on NBC's "The Tonight Show Starring Johnny Carson," on which Mr. Miller appeared many times.

Mostly, he did what all comics do -- work the road. "I was once fired as opening act for Seals and Crofts because I got loaded and introduced them as Arts and Crafts," one of his jokes went.

Born George Wade Dornberger in Seattle, he was raised by his mother after his father left the family when Mr. Miller was an infant.

When he was young, his mother bought him a pool table, and he was hooked. "I was what they call a pool hustler," Miller told the Chicago Tribune in 1986. "That's absolutely true. For long periods of time I got by, barely skimmed by, just playing pool."

Mr. Miller attended the University of Washington, where he "majored in registering," he told the Seattle Post-Intelligencer.

He came to Los Angeles in the late 1960s and performed in the few clubs in which a comedian could find a regular spot -- The Horn in Santa Monica, the Ice House in Pasadena and, several years later, The Comedy Store.

By 1979, when Mr. Miller and others were more established across the country, a group of Comedy Store regulars staged a labor dispute outside the club because they were not getting paid for their gigs. Miller moved on to The Improvisation on Melrose Avenue and the Laugh Factory on Sunset Boulevard, where he continued to perform regularly. By the end of his life, he was living both in a Los Angeles apartment and in his childhood home in Seattle.

His last appearance on "Late Show with David Letterman" was Sept. 4, 2002.

George Miller appeared on David Letterman's show dozens of times.