The Anti-Defamation League of B'Nai B'rith, attempting to respond to a letter to an American paper by Egyptian President Anwar Sadat, said yesterday that Cairo's semi-official daily Al Ahram refused to publish an add from the League.

The Miami Herald published a letter from Sadat on Sunday suggesting that American Jews take a role in making Israel more responsive to his peace efforts.

The Anti-Defamation League's executive council was meeting in Palm Beach and its chairman, Burton M. Joseph, cabled an ad to Al Ahaam in response:

"Respectfully, Mr. President, we suggest that your communique was misdirected. We Americans of Jewish faith are citizens of the United States and therefore not a proper party to the negotiations between your government and the sovereign state of Israel."

Joseph went on to make a broad defense of the Israeli position. A spokesman for the league said Al Ahram at first indicated it would run the reply free of charge. But after further consideration it rejected the response.

Joseph told Al Ahram he was "puzzled by the abrupt change" and he then bought space in today's Miami Herald to run the exchanges as an ad.