The disappearance of James R. Hoffa seven years ago has had a major impact not only on his family, but on organized crime and the entire American labor movement.

His body has not been found. Some of the people close to the case have died. Although no one has been charged with killing Hoffa, many of those investigated are behind bars on other charges. And labor union ties to organized crime are now a major subject of federal investigations nationwide.

A breakdown of what has happened to some of the major characters in the Hoffa case:

* James P. Hoffa, 41, is practicing labor law in Detroit. He represents a number of Teamster locals, including Local 299, where his father started. He said he has no desire to succeed his father as leader of the Teamsters.

* Josephine Hoffa died in 1980 at 62. Her son blames her death on a "broken heart. Her will to live seemed to have gone."

* Charles L. (Chuckie) O'Brien moved to Florida to work for the Teamsters. He has been convicted of several relatively minor crimes and served 10 months in prison in 1979 on a labor law violation. Hoffa said the two are no longer in contact.

* Anthony Giacalone is serving 10 years in prison for income tax evasion.

* His brother, Vito, also a subject of the investigation, was released from prison recently following a felony firearms conviction.

* Anthony Provenzano is serving a 20-year sentence for extortion and a life sentence for ordering the murder of Anthony Castellito. The FBI's Bob Reutter recently said, "Tony Provenzano is going to do mucho time."

* Gabriel Briguglio is serving seven years for racketeering and extortion.

* Salvatore Briguglio was killed in 1978 in a gangland execution.

* Thomas Andretta is serving 20 years for racketeering.

* Stephen Andretta is serving 20 years for racketeering and extortion.

* Frank Fitzsimmons died of cancer last year and was succeeded by Roy Lee Williams, who was questioned intensely by a congressional committee in 1980 about his ties to organized crime. He exercised his Fifth Amendment rights each time he was asked a question about organized crime.

The FBI, largely as a result of the Hoffa case, has re-focused much of its energy into investigations of union corruption and links to organized crime.

The Teamsters, with about 2 million members, is still the largest union in the country, but membership has declined with deregulation of the trucking industry and rising unemployment. The Teamsters Central States Pension Fund continues to be the target of a federal investigation for alleged ties to organized crime.