Secretary of State George P. Shultz accepted the results of a three-year East-West conference here today, at the same time attacking "blatant acts of Soviet defiance" of the spirit and letter of previous accords.

Shultz, speaking to the final ceremonial meeting of the 35-nation Conference on Security and Cooperation in Europe, cited the shooting down of Korean Air Lines Flight 007 three times in a litany of charges against the Soviets.

Shultz charged that the airliner's fate shows "the Soviet Union defines its security in a way so absolute, self-centered and cynical that it poses a danger to all other countries."

Shultz had a special barb for Soviet Foreign Minister Andrei Gromyko, who defended the airliner attack from the same rostrum Wednesday. The U.S. diplomat said that Gromyko had "shamelessly insisted" that the Soviet Union would take the same action in a future case, "thus again demonstrating its callous disregard for human life."

Gromyko did not appear in the hall to hear Shultz's attack or other portions of the final day of speeches about an accord that had been designed to ease the divisions between East and West in Europe. The Madrid conference followed up the 1975 Helsinki accords signed by then-president Gerald Ford, Soviet president Leonid Brezhnev and other leaders as a capstone of the era of detente.

Under the agreements reached here, a series of new East-West conferences is scheduled to be held in the next three years on military, cultural and human rights questions, leading to another large-scale follow-up conference in Vienna in 1986.

Reviewing the decline of detente since 1975, Shultz said, "We must be disappointed but we cannot be surprised" by the setbacks in nearly every field covered by the Helsinki process. He laid the blame in each area on the Soviet Bloc.

Shultz's hard-line speech drew virtually no visible response from the assembled diplomats, who had been laboring here off and on since September 1980 against the background of growing East-West tensions. The downing last week of the South Korean airliner dominated the final ceremonial meetings, providing an ironic counterpoint of bitterness, controversy and invective.

West German Foreign Minister Hans-Dietrich Genscher told reporters as the meeting ended that he was "disappointed" and "gravely concerned" that the Soviet Union did not take the occasion of the meeting here to provide a full explanation for the downing of the airliner.