Presidential candidate Sen. John Glenn (D-Ohio) shook up his campaign staff yesterday, installing Washington lobbyist Thomas H. Boggs, veteran Democratic consultant Robert Keefe and Rep. James R. Jones (D-Okla.) as senior advisers and accepting the resignation of political director J. Joseph Grandmaison.

Grandmaison's departure came after a series of disagreements with campaign manager William R. White over the direction of the campaign. Grandmaison said he had told White more than a week ago that he wanted to quit.

"Today's decisions complete a planned reorganization and restructuring of the campaign designed to be responsive to the changing political conditions that this fall has shown us and to be more effective as we prepare to go into the primaries and caucuses," White said.

Glenn, in a statement transmitted by his director of communications, Greg Schneiders, said, "I am pleased with the progress of the campaign and believe that the changes that Bill has undertaken will strengthen our operations."

Keefe, who ran presidential campaigns for former Indiana senator Birch Bayh and the late senator Henry M. Jackson, was named as senior adviser for political affairs. Jones, chairman of the House Budget Committee, was named senior adviser for domestic policy. Boggs, one of Washington's most active lobbyists, was appointed senior adviser for congressional relations.

Other changes announced yesterday include Charles Smith, Grandmaison's deputy, to be acting political director reporting to Keefe; Leonard Bickwit, a partner in the Washington law firm of Miller & Chevalier and former legislative assistant to Glenn, as issues coordinator reporting to Jones; Jeff Hockman, vice president of U.S. Group, Inc., a Detroit company, as deputy campaign manager, and William Blair, a Canton, Ohio, attorney, as White's executive assistant, replacing Michael Colopy.

The changes grew out of a management study conducted by Hockman.

Grandmaison was known for some time to be upset about his role in a campaign that is relying more heavily on media than on organization.

"I've been particularly frustrated," he said yesterday. "When resources become tight, it's only natural that decisions have to be made to allocate them. It became very, very difficult. I don't mean to suggest that I'm right. Other people may have greater insight than I."

Grandmaison said his departure is no reflection on Glenn. "I continue to admire Sen. Glenn," he said. "It has nothing to do with him. He and Annie Glenn's wife are spectacular people."

Sources said Grandmaison also had differences with White's style of campaign management, citing particularly a lack of leadership and strategy.

One campaign official said yesterday there has been a fundamental disagreement within the campaign over resources and strategy.

Most of Glenn's senior advisers say they believe that the key to winning the Democratic nomination does not lie in field organizations, and that has had an effect on Glenn's state operations.

Glenn's organizations are rated poorly when compared with those of former vice president Walter F. Mondale, and in some states, they rank behind those of Sens. Alan Cranston (D-Calif.) and Gary Hart (D-Colo.).

Yesterday's moves also appeared to strengthen White's hand on the staff. Hockman and Blair are old associates of White.