LeGree Daniels, co-chair of the National Black Republican Council, said yesterday she is resigning, partly out of frustration over the GOP's relationship with blacks.

Daniels, who will remain a member of the Republican National Committee's executive board, said she thinks that the party has "misconnected" with blacks and that blacks have not taken full advantage of opportunities within the party.

"I personally feel there are two doors, going both ways between the Republican Party and black voters," she said, "and while the Republican Party may have misconnected in opening its door all the way, it's also up to blacks to walk through their door.

"I felt I did some things in that all-black organization, but now I really want to focus on integrating the Republican National Committee and everything else instead of working in an all-black setting."

Daniels, a Republican committeewoman from Harrisburg, Pa., who was head of Blacks for Reagan-Bush '84, said her duties will be assumed by Fred Brown, a New York construction company executive who is also co-chair.

She said she will submit her resignation, to take effect next month, this week.

Daniels has headed the National Black Republican Council (NBRC) since 1982 and was reelected in September, despite opposition to her simultaneously heading it and Blacks for Reagan-Bush. After that election, she said, she promised to turn over more control of NBRC activities to Brown but she did not pledge to resign.

Daniels said yesterday she has been "disappointed" in the actions of Clarence M. Pendleton Jr., head of the U.S. Civil Rights Commission, who has strongly criticized fellow black leaders.

"Clarence is having an adverse impact as far as the black community is concerned," Daniels said. "He's saying a lot things, some interesting, but his whole impact is not good for blacks, for Republicans."

She said that while the party could do more to include blacks in its ranks, she is not upset over the scarcity of black appointees in the administration.

"The inauguration was only in January," she said. "I think they are in a recruiting phase . . . but I'm not so concerned with what blacks have jobs in the administration as how the party is attracting blacks at the grass-roots level."

She said she is familiar with complaints by blacks of limited access to President Reagan and of limited patronage for the president's black supporters and that she considers them legitimate but less crucial than increasing the party's "grass-roots appeal to black people . . . to all people."

"The fact that there are few blacks at the White House or that there is criticism of what the few that are there are doing is really a different issue than the party's relationship with blacks," she said. "The president has approved of the way things are being handled over there."