Transportation Secretary Elizabeth Hanford Dole will resign her Cabinet post Oct. 1 to work with her husband, Senate Minority Leader Robert J. Dole (R-Kan.), during his presidential campaign, CBS News reported yesterday.

Dole told the network that she would inform President Reagan of her plans at a 10 a.m. meeting today.

An administration official confirmed late yesterday in an interview with The Associated Press that Dole will meet with Reagan this morning.

However, he would not comment on the specifics of the meeting, saying only that they would "discuss future plans."

The official, who spoke only on condition of anonymity, refused to comment on the Oct. 1 date.

"I can't speak to that," he said. "I guess we'll find out more in the morning."

Sen. Dole is expected to announce his candidacy officially in October.

"I love my job and the challenges it gives me," Transportation Secretary Dole had said Saturday before an appearance for the Dole for President Campaign at a GOP rally at a farm near Lexington, S.C.

"But, as time gets near for Bob's announcement, I will have to assess my situation very seriously," she said.

Dole, a lawyer who has been married to the senator for 12 years, is the only woman in the Reagan Cabinet.

She has held the transportation post for 4 1/2 years.

She has said it is "curious" that people expect a candidate's wife to give up a government job, but made no such demands of candidates themselves.