Massachusetts Gov. Michael S. Dukakis (D), disputing a report in Time magazine, said yesterday he has no knowledge that his supporters put together a videotape highly damaging to the presidential campaign of Sen. Joseph R. Biden Jr. (D-Del.).

At a news conference in Boston, Dukakis said he would be "astonished" and "very angry" if it were proven that any of his campaign staff assembled the tape comparing a Biden speech with an earlier speech by British Labor Party candidate Neil Kinnock.

The tape, which reportedly was given to The New York Times, the Des Moines Register and NBC News, set in motion a series of disclosures that ultimately forced Biden to abandon his bid for the Democratic nomination.

While Dukakis declared that he had no personal knowledge, his campaign manager, John Sasso, said repeatedly "I am not going to engage in it . . . I'm not going to speculate on it," when asked if he knew of any campaign involvement in the production of the tapes and their distribution to the press.

In Iowa, Dukakis' state director, Teresa Vilmain, said "I have no knowledge" of any campaign involvement in the videotape. United Press International quoted Paul Tully, Dukakis' political director, as stating flatly: "It was not this campaign and not our people in Iowa."

At the Boston news conference, Dukakis said Tully's comments "speak for the campaign." He added, "Anybody who knows me and knows the kind of campaigns I run, knows how strongly I feel about negative campaigning . . . I make it very clear to my staff people and I think they know what to expect of me and what I expect of them. I can't be more emphatic than that."

The Time article contended: "A {Des Moines} Register staffer involved in preparing his paper's story has told colleagues that the video was supplied by the Dukakis campaign.

A reliable source says someone connected with the Dukakis presidential campaign also gave the video to The {New York} Times."

Mark Johnson, a spokesman for the presidential campaign of Rep. Richard A. Gephardt (D-Mo.), which also had been accused of leaking the Kinnock tape, said "we are pleased that The New York Times, NBC and now Time magazine have confirmed what we said all along -- that the Gephardt campaign did not do it."

In the 1982 Massachusetts gubernatorial contest, the Dukakis campaign became involved in a minor controversy when it was disclosed that Sasso had privately played a derogatory tape on an off-the-record basis for two Boston Globe reporters. The tape was a parody of a commercial produced by Ed King, Dukakis' opponent in the 1982 election.

On September 11, the Des Moines Register and The New York Times published stories showing that in one speech, Biden used material that was almost identical to the text of earlier speeches by Kinnock during the national elections in England.

These stories led, in turn, to dislosures that Biden had been accused of plagiarism during law school and that he made inflated claims about his academic achievements. Last week, Biden withdrew from the race.