SEATTLE, OCT. 17 -- Republican presidential hopeful Marion G. (Pat) Robertson appeared to question the staunchness of First Lady Nancy Reagan's anticommunism in a remark here Friday that prompted calls from GOP leaders for an apology and a subsequent complaint from the candidate that what he said was misinterpreted.

"My wife does not like communists," Robertson told several hundred party regulars Friday night at the Western States Republican Leadership Conference. "I want to set your mind at ease. She has never suggested that I make an accommodation with the Soviet Union in order to win the Nobel Peace Prize."

The remark was widely interpreted as a swipe at Nancy Reagan, who reportedly has been pushing her husband for an arms-control pact with the Soviet Union and has expressed the hope that he would win the Nobel Peace Prize. Robertson aide George Vinnett confirmed to a Chicago Tribune reporter that the remark was an allusion to the First Lady.

This afternoon, however, after an outcry began to build here, and after Republican National Committee Chairman Frank J. Fahrenkopf Jr. called on Robertson to apologize, the candidate told an airport news conference in Portland, Ore., where he had flown for another campaign event, that "what I said was not meant as a reference to Nancy Reagan at all." He did not say to whom he was referring.

Informed of Fahrenkopf's call for an apology, he said, "I think Frank went off the deep end. There's no apology necessary. I didn't say anything wrong." He added that he had led 500 people in prayer for the First Lady this morning, and noted that his wife had also had a mastectomy.

Connie Snapp, Robertson's director of communications, offered a different interpretation of the comment during a telephone interview from campaign headquarters in Chesapeake, Va. She said Robertson has used the line in speeches for more than a month, acknowledged that it was triggered by reports about the First Lady's hopes for a Nobel Prize for her husband, but said it was intended as a criticism of the news media rather than of the First Lady. "We would never say anything derogatory about her," she said.

The flap comes as Robertson is under fire for changing details of his resume, including his wedding date and war record.

The "accommodation" remark was contained in speech that many in his audience said they thought made similar thinly veiled swipes at the president and several members of his Cabinet. Earlier Friday, Robertson also offended party regulars when he termed Vice President Bush "a whiny loser."

"It's a real turn-off for party regulars," said California GOP Chairman Bob Naylor. "It makes him seem like a real extremist," he said.

Robertson, the television evangelist-turned-candidate, used his half-hour dinner address to paint a vivid picture of how his administration would look and what kind of policies it would pursue.

The only light moment in a staccato presentation that "left no ducks standing," in the words of Rep. Denny Smith (R-Ore.), came when Robertson concluded by deadpanning: "Ladies and gentlemen, there's my program for my first six days in office -- and the seventh day, I will take a rest."

Before that, Robertson said:"As the nominee of the Republican Party, I would have no interest, in reaching out for a vice president, to choose a liberal with whom I disagree with in order to balance the ticket ideologically." The comment was an apparent reference to Reagan's selection of then-Sen. Richard S. Schweiker (R-Pa.) as his ticket-mate in an unsuccessful effort to win the 1976 Republican nomination. "I would appoint as secretary of state someone who would stand up for America instead of someone who would try to move the nation toward a one-world socialist government." Many in the audience took that as a reference to Secretary of State George P. Shultz, long the bane of conservatives. "In the White House, I would appoint a chief of staff much like {Secretary of Interior} Donald Hodel rather than some moderate who would please The Washington Post." He would not negotiate an arms deal with Soviet leaders, whom he called "liars," until they "get out of Afghanistan, take down the Berlin Wall and release the prisoners from the gulag." "If I were president today, we already would have taken out those Silkworm missiles" in the Persian Gulf.

On domestic issues, Robertson said he would "close down the federal government" rather than sign any spending bill that included "one dime for Planned Parenthood"; move control of education away from "the Washington headquarters of a powerful teachers lobby with leftist tendencies," and favor mandatory life sentences with no chance of parole for drug pushers convicted of a second offense.

Audience reaction was mixed, and Robertson's applause lines seemed to lose their punch as the peroration continued. "He was trying to out-Reagan Reagan," said Elwood English, secretary of the Montana Republican organization. "Most of it, I liked very much," he said, but added that he found the apparent reference to the First Lady a "cheap shot."

Smith echoed the sentiments of many when he said he found it "odd" that Robertson would give such a raw-edged talk to a group of party regulars. He said it was no way to "broaden his base."

In comments before the speech, Robertson showed little regard for the Republican Party's "11th commandment," that "Thou shalt not speak ill of other Republicans." Asked to respond to a comment by Bush that Robertson's supporters in Michigan had engaged in "kamikaze warfare," Robertson called him a "whiny loser." Robertson forces claim they will win at least 44 of that state's 77 delegates when the first caucuses are held in January.

Fahrenkopf dismissed the comments as part of the inevitable "testiness" of a campaign, but noted that Reagan will discuss the "11th commandment" when he meets at the White House Tuesday with all the GOP candidates.

Reaction to Robertson's speech dominated today's session, but three other candidates also appeared and took issue with Bush's "challenge" -- in his announcement speech last week -- that they support the proposed intermediate-range nuclear missile agreement with the Soviets.

"I'd like to see it first," said Senate Minority Leader Robert J. Dole (R-Kan.), who said he had concerns about verification.

Former Delaware governor Pierre S. (Pete) du Pont IV criticized Bush for taking a "sign now, negotiate later" approach to arms control.

Rep. Jack Kemp (R-N.Y.) said he does not think "we should sign any agreement with the Soviet Union until they show they can keep the prior ones."

Former U.N. ambassador Jeane J. Kirkpatrick said at a news conference that she will decide by Oct. 28 whether to seek the nomination.