D.C. Mayor Marion Barry, declaring he will make a "crusade against drugs my number one priority in 1988," touted a get-tough agenda of antidrug measures yesterday and strongly suggested that he will seek higher taxes to meet the rising cost of major city services.

Pledging a "citywide attack" and calling for increased neighborhood activism, the mayor proposed a drug summit with the governors of Virginia and Maryland and other regional leaders, and laid out plans for new school and job training programs to aid youths "at risk."

Barry, under fire for cutting back on Operation Clean Sweep, also said he will announce major new police initiatives soon.

The mayor outlined his plans in a generally upbeat 40-minute State of the District address delivered at the Kennedy Center. Invoking memories of the riots 20 years ago, he hailed the city's progress since then but decried a recent spate of drug-related killings.

"Drugs threaten our stability. Drugs threaten our safety . . . and drugs threaten the soul of our city," Barry said in a speech that was interrupted frequently by applause from the crowd of more than 2,000. The assemblage included the mayor's Cabinet members, government workers, business leaders, senior citizens and 500 public school children bused in for the occasion.

Barry's speech was generally met with enthusiasm, but D.C. Council members reacted with caution to his passing comment that he "may have to call on you for revenue enhancements to support our programs." Barry, who is to present his fiscal 1989 budget on Feb. 8, declined to be more specific with reporters about a tax increase.

Council member John A. Wilson (D-Ward 2), chairman of the Finance and Revenue Committee who twice led successful fights last year to block Barry's proposed income tax increases, said, "I don't think {a tax proposal} would be greeted kindly, but it would be given a fair hearing . . . . At the moment, I'm not willing to accept anything."

Among the other major proposals in the speech were:A juvenile justice initiative called "Invest in the Future" that would coordinate new and existing programs designed to help young people. Plans to expand cash awards to high school scholars. Barry proposed giving $1,000 to public school students who graduate in the top 10 percent of their class, a proposal that could cost more than $400,000 annually. Barry later told reporters that he may also offer similar cash awards to an unspecified number of students who are designated as "most improved" by schools regardless of their grade averages. Creation of a "mobile city hall . . . to bring services of the government to every corner of the city." Barry said he would accompany the vehicle at times to see problems firsthand. Targeting job training and development specifically in neighborhoods east of the Anacostia River in Wards 6, 7 and 8, with a particular emphasis on redeveloping a portion of St. Elizabeths Hospital. Establishment of a new downtown jobs center and the opening of a business and career center for minority youths interested in establishing businesses.

Acknowledging shortcomings in his staff, Barry said he is shaking up his administration to fill several key jobs that are vacant or held by acting officials.

On allegations of corruption in government, Barry said there will always be some who steal but added, "I will not tolerate that from anyone in this government."

Some of the most sustained applause came when Barry sharply criticized the news media, saying there "are some journalists who call every problem a setback . . . who would rather peep in our bedrooms than report our accomplishments . . . who would rather make the news than report the news . . . who think of themselves as judge, jury and executioners."

Many city officials in the crowd cheered wildly and stared up at a balcony filled with reporters and television cameras. Barry later refused to identify the reporters or news organizations to which he referred.

Barry did not specify when he might seek the regional summit with Virginia Gov. Gerald L. Baliles, Maryland Gov. William Donald Schaefer and suburban officials to draft antidrug policies.

The mayor, in seeking more regional cooperation, said the District handles a disproportionate share of the area's social problems, such as homelessness, and called on the city's wealthier neighbors to do more. Drugs "know no city boundaries," Barry said, adding that "Washington will no longer be the region's drug marketplace."

Baliles' press secretary, Chris Bridge, said the governor was unaware of Barry's regional summit proposal and would need more details. "Obviously it's in the region's interest," said Bridge.

Schaefer spokesman Bob Douglas said, "I don't believe the governor has been contacted by the mayor. However, a few weeks ago {Schaefer} said the state of Maryland needs to work on a regional basis to solve several problems including drug trafficking . . . .

"The governor will be pleased to know the mayor supports his suggestion."

An aide to Prince George's executive Parris Glendening said Barry talked about the summit last week with Glendening and that the county executive is "all in favor of it."

Staff writer Linda Wheeler contributed to this report.