The pioneers came in the late 1920s, lured to the uninhabited Siberian forests and mosquito-infested swamps by a mixture of communist ideological fervor and their dream of a Jewish homeland.
They pitched tents and planted farms. They were followed by thousands of others -- cobblers and barbers, haberdashers and milliners -- fleeing famine and the Nazis, hoping somehow to make a better life.
Joseph Stalin encouraged settlers in the Jewish Autonomous Region to develop a community that would keep alive traditions such as the Yiddish language and Jewish songs and dances. But the religion itself -- synagogues, holidays, formal worship -- was stamped out.
"Stalin's idea was to get inside the fruit, take out its heart and leave only the peel. That's why there were signs in Yiddish, and there was a school in Yiddish, but as far as the religion was concerned, it simply wasn't there," said Rabbi Mordechai Sheiner, who moved to the region's capital, Birobidzhan, from Israel in 2002. "Maybe somewhere in a basement someone observed some rites."
But today, as religion experiences a resurgence across Russia in the wake of the Soviet Union's collapse, this far eastern Siberian region along the Manchurian border near Khabarovsk has become one of the nation's most important centers of Jewish life.
Last September, Sheiner opened the area's first formal synagogue in seven decades. The Freid Jewish Community, the main Jewish organization in Birobidzhan, now runs a school attended by about 100 children that meets on Sundays, teaching Hebrew, Jewish traditions and activities such as dancing.
The community has also purchased a building in which it plans to open a Jewish school, probably next year, that would start with a limited number of grades but eventually serve kindergarten through high school, Sheiner said.
"There's no question that the Jews there feel much more Jewish than anywhere else in Russia, and not because of their history or what they've gone through, but mainly because of the new opportunities they have there," Russian Chief Rabbi Berel Lazar said.
It's not that the area has the nation's largest population of Jews. Out of the 190,000 people in the autonomous region, Lazar estimated that there are only about 5,000 Jews -- although counting is difficult because children of Jewish fathers and non-Jewish mothers may think of themselves as Jews but are not considered so by religious law unless they formally convert.
But Birobidzhan, a city of 77,000, has a Jewish flavor that extends beyond the small percentage of its population that is Jewish.
Numerous signs are in Yiddish as well as Russian, including the lettering on a monument marking the city boundary. A billboard for Sholom Motors greets drivers soon after entering town. In front of the train station, a huge menorah rises out of a fountain.
Birobidzhan has long had a state-run school called the Jewish School that has about 225 students and includes Hebrew among its course offerings. But community leaders do not view it as capable of passing on the Jewish faith to students. "It was the Jewish school from old times," Sheiner said, "but it didn't really correspond to its name in religious terms."
Now, the Freid Community -- which is aligned with a nationwide Jewish organization headed by Lazar, one of two chief rabbis in Russia -- sponsors the Birobidzhan Jewish People's University. It has 60 students, said Lev Toytman, the community's chairman.
Toytman, 79, was among the early settlers, arriving here as a child with his mother and stepfather in 1934, the year the autonomous region was formally established. Efforts to settle the region, which lies along the Trans-Siberian Railway, had begun in 1928, with trailblazers living in tents as they drained marshes and cut down forests.
"At first there were Jewish collective farms and state farms here, and industrial enterprises began to be built," Toytman recalled. "There was a period when there were up to 46,000 Jews here."
But many of the newcomers didn't stay long. Most were "tailors, hat-makers, shoemakers, barbers, hairdressers," Toytman said. "Agriculture wasn't attractive to them, but they had to build everything from scratch, and not everyone could cope with that.
"There's another small detail: All this was mainly swamp, and there were so many mosquitoes and black flies that people couldn't stand them," he said. "That's why many people left."
Foreign Jewish leftists were among the pioneers. There was even a Jewish-American commune in the region, but it was destroyed after Stalin launched a nationwide campaign of repression and terror in the late 1930s, Toytman said.
"It was a commune that had an extremely high technical level for Russian standards at the time," he said. "In 1938, it practically ceased to exist. Only women and children remained. All the men were arrested and shot. They were all considered American spies, counter-revolutionaries, although all of them were communists. They were all Jews who came from the United States."
During and after World War II, migration to the region surged again as Jews sought it out as a haven. "During the war, a lot of Jews were evacuated from Ukraine, from Lithuania, from Latvia," Toytman said. "They came here and they survived. My wife with her brother also fled here during the war."
From the 1950s through the mid-1980s, the region's Jewish character gradually dissipated, although it never quite disappeared.
The new openness that came under former Soviet president Mikhail S. Gorbachev made emigration possible, and about half the region's remaining Jews moved away, most to Israel. But it also allowed a small renaissance of Jewish culture.
The future of Jewish life in the region depends on people like Ksenia Malyarskaya, 23, who was born in Uzbekistan, the daughter of a Jewish father and non-Jewish mother. Her father was born and grew up in the Jewish Autonomous Region, and in 1994 he brought the family home.
Now, she keeps a database on participants in Freid Community activities, part of an effort to build the group's size and strength. She said it really doesn't matter that she may not "technically" be Jewish because her mother is not Jewish; she still intends to raise her children to be Jewish and does not seem overly concerned about the issue of formal conversion.
"Here in Russia, the general notion is that if you think you are a Jew, then you are a Jew," she said. "I think that I am Jewish."