John Doub, a 25-year-old draftsman from Waynesboro, Pa., pulled away from the pack in the second mile yesterday in Rock Creek Park, then held the lead for the rest of the course to win the fifth Hecht 10-Miler in 50 minutes 33 seconds.

Doub, who trained for the race in the hills of Pennsylvania and western Maryland, finished about 50 yards ahead of occasional training partner Ned Poffenberger, 25, of Hagerstown, who was second in 50:40.

Cynthia Lorenzoni, 23, of Charlottesville, finished first among the women in 58:21, her second straight victory in the Hecht race. Lorenzoni, who also won the women's prize in last fall's Marine Corps Marathon, easily defeated Debra Pavik, 23, of Lutherville, Md., who finished in 60:18.

Approximately 1,500 runners participated in the race, which began at the Carter Barron playing field at 16th and Kennedy Streets NW, followed a hilly and winding course through Rock Creek Park, and then ended in the Carter Barron parking lot about a quarter-mile from the starting point.

Because of the hills and Washington's typical warm, humid June weather, the race is known as one of the more difficult 10-mile contests on the East Coast. But the runners got a break yesterday. The temperature at the 8:30 a.m. starting line was only 68 degrees and the humidity was below the discomfort level.

Nevertheless, it was clear that experience on hilly terrain was an advantage. Lorenzoni, Doub and Poffenberger all train in the mountains.

"There is a loop in the race where it looks flat, and that's where you tend to lose your concentration," said Lorenzoni, who led the women runners from the starting line. "The hills don't bother me, because that's where I train. There is a tough hill just before mile nine (coming up out of Rock Creek Park), but I was ready for it. I'd rather run here than at Hains Point, because its always so windy down there."

Doub, who was running in his first Hecht 10-Miler, said, "I tried to set a quick early pace going down the hill into Rock Creek Park. I wanted to get a comfortable lead and keep it. Coming back up the hill at the end of the race, I almost passed out. I was feeling lightheaded, but I knew when I got to the top, no one could catch me.

"Ned (Poffenberger) and I train together, so I know what kind of kick he has at the end of a race. These hills are mild compared to the kind of mountains we run in."

Finishing third among the men was Victor Elk of Quantico, who finished in 51:16. Christopher Stewart, winner of the 1981 Baltimore City Marathon and a British 5000-meter champion, was fourth in 51:42, and Dan Rincon of Silver Spring, winner of the 1980 Hecht 10-Miler, was fifth in 51:55.