The debut of Cleveland Manager Mike Ferraro was successful as Andre Thornton hit a three-run home run on his first swing of the season and Toby Harrah had four of the Indians' 15 hits before 34,841 in Oakland.
Thornton homered over the left field fence after singles by Harrah and Bake McBride. His home run gave the Indians a 3-0 lead in the first inning and the A's never caught up.
Rick Manning had three hits and Mike Hargrove, George Vukovich, Ron Hassey and Julio Franco each had an RBI. Seven of the Indians' hits came off Rick Langford, who lasted less than four innings and was the loser.
Rick Sutcliffe, who started the 1982 season in the bullpen, went 6 1/3 innings and, with help from Ed Glynn and Dan Spillner, earned the victory. The A's had 10 hits, seven of them off Sutcliffe.
Rookie Kelvin Moore's two-run homer in the sixth drew the A's within two, but Hassey's RBI single and Bob Kearney's second passed ball gave the Indians two more runs in the seventh.
The game also marked the big-league managerial debut of Oakland's Steve Boros, who used four pitchers in a game that ran more than three hours.