Julio Cruz hit a two-out, two-run single off Bob Stanley in the 11th inning to give Chicago victory in Boston's annual Patriots Day morning game.
Ozzie Guillen led off the 11th with a walk. Greg Walker singled off Stanley's foot and Rudy Law's ground ball to first advanced the runners.
"I didn't want to go oh-for-six," said Cruz, who entered the game with a lifetime average of .199 when coming to bat with runners in scoring position and two out. "All I wanted to do was make hard contact." Cruz, who has three hits in 20 at bats this season, sent a 2-2 pitch from Stanley into left field.
Cruz admitted that he hasn't had much success against Stanley. "Stanley usually gets me out," said the second baseman. "All I did was extend my bat and the ball hit it."
Winner Al Jones gave up a run in the bottom of the 11th when Glenn Hoffman led off with a double, moved to third on an infield out and scored on a passed ball.
Boston, trailing, 4-3, entering the ninth, tied it when Rick Miller doubled off reliever Bob James and scored on Jim Rice's two-out single.
The White Sox jumped to a 2-0 lead in the second on a single by Tom Paciorek, a double by Fisk and two-run single by Luis Salazar.
Tom Seaver, seeking his 290th career win, shut out the Red Sox until the fifth when Rich Gedman doubled and scored on a single by Wade Boggs, who hit safely in his sixth consecutive game this year and 17th straight over two seasons.