Buddy Bell and Tony Perez knocked in first-inning runs and right-hander Jay Tibbs (8-15) allowed seven hits in eight innings to give Cincinnati the victory at home. Ted Power earned his 21st save.
Andy Hawkins (17-6) lost a six-hitter and his team has lost 10 of its last 13 games.
The Reds' player-manager, Pete Rose, who broke Ty Cobb's all-time hit record Wednesday night, did not play because he got little sleep overnight. He made nationwide television appearances on three shows.
"Everybody was emotionally drained from last night," Reds outfielder Eric Davis said. "We went from 47,000 people in the seats to 13,000. That didn't pick us up."
The Reds honored Rose's record by painting a circle with the number 4,192 in left-center field. The circle marks the spot where Rose's first-inning single landed on the artificial turf Wednesday night. Reds officials watched taped replays to locate the spot where the single landed. The circle will stay in the outfield at least through the remainder of this season, a Reds spokesman said.
The city of Cincinnati put up signs renaming the street that borders Riverfront Stadium "Pete Rose Way."