Maryland's football team learned yesterday it will have to play the final three games of the season without two starters -- running back Mike Anderson and right guard Dave Amend.

Amend will have surgery next Friday after hurting his right knee in practice Wednesday. Anderson will be kept out of action because of side effects from his treatment for leukemia, according to Coach Joe Krivak and trainer J.J. Bush.

"There are no leukemia problems," Bush said in a statement released through the Maryland sports information department. "It is the side effects from the treatments that make football not in his best interests at this time."

Krivak said, "It's a reaction to the medication rather than the disease. That's under control. The medication causes sweating, tiredness and nausea. They said that he shouldn't play the rest of the year."

In July, Anderson, a junior who went to DeMatha High School, was diagnosed as having leukemia. He has been treated since then at the University of Maryland Cancer Center in Baltimore. Dr. Edward Lee, who has treated Anderson at the Cancer Center, declined to comment at the request of Anderson's family.

Anderson had responded so well to initial Interferon treatments that doctors allowed him to resume playing. His first game back was the third one of the season, Sept. 19, and his presence helped inspire the Terrapins to a 25-20 victory over West Virginia.

"It's disappointing," Anderson said yesterday. "It's something we knew about, the doctor had predicted it. But it was a decision we had to make."

Anderson, who still will go to class and observe practice, said the disease is in check. "That's doing fine," he said. "The medication works great. It's just hard to go out and go through the grind with the side effects."

"I certainly can't question them," Krivak said of the doctors' decisions. "We were fortunate to have Mike play for us as much as he did {six games}. The main thing is that he has it under control. That's the big thing."

Before practice, Bush said, "It's strictly medical. I think the doctors felt that because the drug was working so well on the leukemia, it was not worth it to stop just to do away with the side effects."

Anderson, a 5-foot-9 1/2, 186-pound junior from Capitol Heights, had become an important member of the Terrapins offense. Along with Bren Lowery and Dennis Spinelli, Anderson was one of only three backs who have seen extensive playing time. Anderson, who would have started Saturday, played both fullback and tailback, and had gained 168 yards and scored three touchdowns on 41 carries while catching nine passes for 65 yards.

The Terrapins have had difficulty moving the ball on the ground, and Anderson's departure from the lineup only put a greater crimp in the attack.

"You better believe it," Krivak said. "Especially, since Lowery was sick {Wednesday}."

Lowery, who will start at tailback, had some flu symptoms but did practice yesterday. Spinelli, who has several minor aches, will start at fullback. The substitutes will be sophomore Arnold Walker (one carry, six yards), freshman Mike Beasley (one carry, seven yards) and senior Richard Shure (no carries).

Amend hurt his right knee in practice Wednesday. The senior from Baltimore tore part of the lateral cartilage and stretched part of the lateral ligament.

"I haven't had real good luck over the years," Amend said yesterday. "I've had ankle injuries, I missed one preseason because of pneumonia. Then I had neck spasms. It's never been anything real serious, but they've been enough to put me out for a couple games. It's frustrating."

Amend, a kinesiology major, said he will be able to graduate at the end of next summer, although if he had an opportunity for a pro tryout, that schedule would be pushed back.

Krivak told the squad before practice that it would be without Anderson and Amend. Senior Joe Giuliano will take Amend's spot at right guard.

"Everyone knows they contributed a lot to the team," tight end Ferrell Edmunds said. "Now, all we can do is play hard and try to find replacements."

The Terrapins (4-4) are coming off a 27-14 loss to North Carolina that has all but eliminated them from bowl consideration or for an Atlantic Coast Conference title. Saturday they play Penn State in Baltimore before finishing the season on the road against Clemson and Vanderbilt.

"We've got to go with what we've got," Krivak said. "All we can do is play as hard as we can."