Mickey Joseph ran for four touchdowns in the first half and threw for another as No. 7 Nebraska rolled over Missouri, 69-21, in a Big Eight game yesterday in Lincoln, Neb.

Nebraska (6-0, 2-0), which totaled 622 yards offense, assured itself of a 29th consecutive winning season, an NCAA record.

Joseph's touchdown runs of 15, 5, 2 and 3 yards in the first half tied a school record for quarterbacks set by Gerry Gdowski last year against Iowa State. Joseph also threw 10 yards to Jon Bostick for another score.

Leodis Flowers, who had 111 yards rushing by halftime and sat out the second half with a bruised knee, became the first Cornhusker to run for 100 yards or more in four consecutive games since Doug Dubose in 1984.

Kent Kiefer led Missouri (2-4, 0-2) by hitting 16 of 31 for 202 yards against Nebraska's nation-leading pass defense, but was intercepted twice.

Notre Dame 57, Air Force 27: In South Bend, Ind., Rick Mirer (253 yards passing, two touchdowns) and Raghib "Rocket" Ismail (career-best 172 yards on six receptions) helped the eighth-ranked Irish (4-1) rebound from last week's 36-31 loss to unranked Stanford.

Dorsey Levens, in his first start at tailback, rushed for two first-quarter Irish touchdowns, settling matters early for Air Force (3-4).

Illinois 34, Purdue 0: Jason Verduzco completed 21 of 34 passes for 329 yards and two touchdowns, paving the way for the No. 11 Illini (4-1, 2-0 Big Ten) at home. The Boilermakers are 4-5, 0-2.

Colorado 28, Iowa St. 12: Darian Hagan, who wasn't expected to play because of a sprained left shoulder, directed touchdown drives on three of four possessions, lifting the 14th-ranked Buffaloes (5-1-1, 2-0 Big Eight) at home.

Hagan came off the bench and produced the go-ahead score at the end of the first half on a three-yard pass to tight end Sean Brown. He engineered scoring drives of 80 and 84 yards in the third quarter.

Iowa State is 2-3-1, 0-1-1.

Indiana 27, Ohio St. 27: In Bloomington, Ind., a holding penalty cost Indiana a go-ahead touchdown with less than two minutes to go, and the 22nd-ranked Hoosiers (4-0-1, 1-0-1 Big Ten) had to settle for a 27-yard field goal by Scott Bonnell.

Ohio State is 2-2-1, 0-1-1.

Iowa 30, Wisconsin 10: Tailbacks Nick Bell (146 yards rushing) and Tony Stewart (124) each scored a touchdown to power the No. 25 Hawkeyes (4-1, 2-0 Big Ten) and continue the Badgers' woes in Iowa City, where they haven't won since 1974. Wisconsin (1-4, 0-2) has lost 17 straight road games, dating from 1986.

Minnesota 35, N'western 25: Mark Smith ran for two touchdowns and Marquel Fleetwood threw scoring passes of 65 and 55 yards as the Golden Gophers (3-2, 2-0 Big Ten) handed the Wildcats (1-4, 0-2) their 15th straight road loss.

Kansas St. 23, Okla. St. 17: Carl Straw, after hitting a long third-down pass with defenders pulling him down, scored the go-ahead touchdown on a one-yard run as the Wildcats (4-2, 1-1) rallied at home for their first Big Eight win in four years. The Cowboys (2-4, 0-2), who had not lost in Manhattan since 1978, had first and goal from the 10 late in the fourth period but fumbled.

N. Illinois 35, Arkansas St. 0: Corey Ray scored two touchdowns in leading the Huskies (4-3) to their first shutout in five years and 12th straight win at home. The Indians fell to 3-3-1.