Louisville, off to its best start in 19 years, turned a 99-yard first-half drive and John Gainey's second-half interception into two short-range touchdown runs by Curtis Lipsey to upset Pittsburgh, 27-20, yesterday in Pittsburgh.

Browning Nagle, who suffered a sprained ankle, sprained knee and separated shoulder in the first half, recovered to throw a seven-yard touchdown pass to Ken McKay in the third quarter as Louisville (6-1-1) moved closer to its first bowl bid since 1977.

The Cardinals' start is their best since they went 9-1 in 1972.

Pitt fell to 3-1-1.

Penn State 40, Boston College 21: Third-stringer Shelly Hammonds ran for 208 yards and scored twice as the Nittany Lions (4-2) overcame the Eagles (3-3) in Newton, Mass.

Hammonds, who previously carried only four times for the varsity, set a Penn State record for a sophomore, 16 more than Jon Williams's total against Notre Dame in 1981. Hammonds broke a tie with a 65-yard run at the outset of the second half and added an insurance touchdown on a 48-yard sprint with less than 2 1/2 minutes remaining.

Syracuse 42, Rutgers 0: Mark McDonald, subbing at quarterback for injured Marvin Graves, ran for one touchdown and threw for one to lead the Orangemen (3-2-2) to a rout of the Scartlet Knights (2-5) in Syracuse, N.Y.

Colgate 31, Fordham 7: Dave Goodwin threw four touchdown passes, two each to George Delaney and Dan McCarthy, as the Red Raiders (5-2, 1-0) beat the Rams (1-5, 1-0) in the Patriot Conference game.

Massachusetts 17, Delaware 3: Eric Thimas returned a punt 61 yards for a touchdown to break the game open as the Minutemen (5-0-1, 5-0) ended 32 years of frustration against the Blue Hens (4-3, 3-2) with a Yankee conference victory in Newark, Del.

Army 56, Lafayette 0: Myreon Williams caught three touchdown passes from three quarterbacks and Ed Givens returned an interception 100 yards for a score as the Cadets (3-3), playing at home, ended a three-game losing streak with a rout of the Leopards (3-4).

Harvard 23, Princeton 20: Scott Johnson kicked a 34-yard field goal with 55 seconds to play to give the Crimson (4-2, 2-1) the win over the Tigers (2-4, 1-2) in an Ivy League game in Princeton, N.J.

Dartmouth 11, Cornell 6: Dennis Durkin kicked three field goals and the Big Green (3-2-1, 2-1) rebuffed heavy pressure at the end in beating the Big Red (3-2, 2-1) in Ithaca, N.Y.

Brown 24, Penn 17: Rodney Vincent rushed for 120 yards and Brett Brown added 112 yards and a game-winning touchdown run with 55 seconds left as Brown (1-5, 1-2) upset the visiting Quakers (2-4, 2-1).

Yale 31, Columbia 7: Kevin Callahan scored three times in the third quarter as the Bulldogs (3-3, 2-1) whipped the Lions (0-6, 0-3) in New Haven, Conn.