Mike Greenwell received the biggest contract in Boston Red Sox history yesterday, agreeing to a four-year deal worth approximately $12 million.

The left fielder had threatened to become a free agent after the 1992 season if he didn't get a multiyear deal. He made $1,225,000 in 1990.

"Mike is an integral part of this team," Red Sox General Manager Lou Gorman said. "Neither side wanted to go to arbitration, so we are pleased to get this done. With a four-year deal, we have bought out two years of possible free agency."

Greenwell hit .297 last season with 14 homers and 73 RBI. His status as Boston's top-paid player, however, probably won't last long. Roger Clemens is negotiating a contract extension that will be worth well over $4 million a season and possibly more than $5 million.

Others avoiding arbitration include Angels right-hander Kirk McCaskill, Reds shortstop Barry Larkin and Pirates right-hander Bill Landrum.

Cardinals right-hander Todd Worrell, sidelined all of last year, took a cut in base pay.

McCaskill doubled his salary, avoiding arbitration by agreeing to a one-year deal worth $2.1 million. McCaskill was 12-11 with a 3.25 ERA in 29 starts for California last year. He had surgery after the season to remove loose pieces and spurs in his right elbow.

McCaskill had asked for $2.4 million while the Angels had offered $1.65 million. Last year, he made $967,500.

Larkin more than doubled his salary to $2.1 million. He made $835,000 in 1990, batting .301 in 1990 with seven homers and 67 RBI.

Landrum, whose arbitration hearing was scheduled for Monday, agreed to a one-year deal for an undisclosed salary. Landrum had asked for $990,000 and the club had offered $700,000.

Landrum led the Pirates with 13 saves last season. He was hampered by a sore left knee the second half and had calcium deposits surgically removed from the knee Oct. 16.

Worrell and right-hander Bob Tewksbury agreed to one-year deals with St. Louis.

Worrell will earn a base salary of $660,000, and incentives could raise his pay to $950,000 if he pitches in more than 81 games. He was paid $825,000 last year.

Worrell had elbow surgery in December 1989. Last year Lee Smith led the Cardinals with 27 saves and a 2.10 ERA.

Tewksbury will earn $160,000 and can boost his total to $185,000 if he starts 30 games. He was 10-9 with a 3.47 ERA in 1990, starting 20 games and relieving eight.

Three right-handed pitchers also settled. Mike Henneman, who made $335,000 last season, tripled his salary when he and Detroit agreed to a $1.1 million deal. Chris Bosio and Milwaukee agreed at $875,000, a $165,000 raise. Right-hander Pete Smith and Atanta settled at $365,000, a raise of $175,000.

And outfielder Otis Nixon and Montreal agreed to $585,000, a raise of $270,000.

There was no decision in the cases of San Diego catcher Benito Santiago and Montreal outfielder Mike Aldrete, who appeared before arbiters on Wednesday. Second baseman Roberto Alomar and Toronto had a hearing yesterday.

Free agent left-hander Don Carman agreed to a one-year, $450,000 contract with Houston. Carman was 6-2 with one save in 59 games with Philadelphia last season.

The New York Yankees designated left-hander Dave LaPoint for assignment to make room for minor league outfielder Mike Humphreys, who just arrived from San Diego.

LaPoint, who is guaranteed $900,000 this season, must be released or traded within 10 days. He also can be sent to the minors, but only with his permission. He was 7-10 with a 4.12 ERA last season.

Humphreys is the player to be named in the deal that sent outfielder Oscar Azocar to the Padres in December. He spent most of 1990 with Wichita of the Texas League, hitting .276 with 17 homers and 79 RBI.