Andre Agassi's path at the U.S. Open could include a quarterfinal against No. 1 Roger Federer, while defending champion Andy Roddick might have to play 2000 winner Marat Safin in the fourth round.

Serena and Venus Williams wound up on opposite sides of the field in yesterday's draw, so they can't play each other until the final.

In addition to Agassi-Federer, the potential quarterfinals are Roddick vs. No. 7 Juan Carlos Ferrero in a rematch of the 2003 final, 2001 Open champ Lleyton Hewitt vs. No. 8 David Nalbandian, and No. 5 Tim Henman vs. No. 3 Carlos Moya.

Agassi, whose eight major titles include the 1994 and 1999 Opens, will face U.S. Davis Cup player Robby Ginepri in the first round.

Roddick -- who lost to Safin at the Australian Open this year -- starts against Scoville Jenkins of Atlanta, the first black to win the USTA Boys' 18s national championship. In the second round, Roddick will play James Blake of the United States or Rafael Nadal of Spain, an 18-year-old who won his first ATP Tour title this month in Sopot, Poland.

Federer's first-round opponent is 2002 French Open champion Albert Costa.

Third-seeded Serena Williams is slated for a quarterfinal against No. 8 Jennifer Capriati. Other possible women's round-of-eight matchups are defending champion Justine Henin-Hardenne vs. Wimbledon champion Maria Sharapova, 1998 U.S. Open winner Lindsay Davenport vs. French Open champion Anastasia Myskina, and No. 2 Amelie Mauresmo vs. No. 6 Elena Dementieva.

Venus Williams faces a tougher road than she is used to at majors. The two-time U.S. Open winner and two-time runner-up could play No. 20 Chanda Rubin -- her Olympic doubles partner -- in the third round, and Davenport in the fourth.

At least she won't have to play her sister early. They could have been drawn into a quarterfinal matchup, because Venus's protected ranking expired and her seeding is only No. 11.

Organizers announced that Lina Krasnoroutskaya of Russia, who would have played No. 13 Paola Suarez in the first round, pulled out of the tournament with a strained right wrist. Her spot in the draw will be taken by a player who lost in qualifying.

-- From News Services

Andre Agassi, shown at the Legg Mason Tennis Classic, could face Roger Federer in the U.S. Open quarterfinals.