Baltimore (-3) at Cleveland, 1 (WUSA-9, WJZ-13)
Jamal Lewis rushed for 205 yards and two touchdowns in the teams' last meeting, and rushed for 500 total last season against the Browns, an NFL single-season record for rushing yards against one team. Defensive end Kenard Lang is promising better results this time: "He ain't going to break the first line of defense," he said. "That's it, that's all I'm going to say. He ain't going to break that first line of defense."
Oakland (+4) at Pittsburgh, 1
Norv Turner and Warren Sapp make their Raiders debuts against a Pittsburgh team that held Oakland to just 161 total yards in a 27-7 win last season. Pittsburgh Coach Bill Cowher has said Duce Staley will start at running back but that veteran Jerome Bettis will play as the Steelers try to improve on their 31st-ranked rushing offense from a year ago.
Arizona (+11) at St. Louis, 1
Poor Dennis Green. The first-year Cardinals coach begins the season with a quarterback (Josh McCown) who has started three games in his career, a running back (Emmitt Smith) who is well past his prime and three wide receivers (rookie Larry Fitzgerald, Karl Williams and Nate Poole) who had a combined 20 catches last season.
Jacksonville (+3) at Buffalo, 1
Jacksonville running back Fred Taylor carried the ball only six times in preseason games while nursing a strained foot, and the Jaguars' first-team offense failed to score a touchdown. But Taylor practiced this week and is probable today, which is a good thing for Jacksonville: The Jaguars compiled a 5-1 record when Taylor had 24 or more carries last year.
Detroit (+3) at Chicago, 1
Former Rams defensive coordinator Lovie Smith makes his head coaching debut for the Bears, while former Chicago coach Dick Jauron gets his Detroit debut as defensive coordinator. The Lions are hoping to end their 24-game road losing streak, the longest in NFL history.
San Diego (+5) at Houston, 1
The Texans have won both of their season openers and are looking to become the first team in NFL history to win their first three. A bunch of people are pegging Houston as a sleeper team this season, but its offense and defense ranked 31st in the league last season.
Seattle (-2) at New Orleans, 1
The New Orleans defense begins a tough stretch against a Seahawks offense that ranked sixth a year ago. The Saints' next two games are against the 49ers (ranked fifth last year on offense) and St. Louis (ranked ninth).
Cincinnati (+41/2) at New York Jets, 1
After sitting all of last season, 2002 Heisman Trophy winner Carson Palmer makes his debut for the Bengals. He can look at Jets quarterback Chad Pennington for inspiration. Pennington sat for almost all of his first two seasons in the league, then threw for 22 scores in 2002.
Dallas (+41/2) at Minnesota, 4:15
We finally get to find out if Bill Parcells's age-based gambles pay off. He's starting Vinny Testaverde at quarterback and Eddie George at running back (with the banged-up Julius Jones as his understudy) after passing on Stephen Jackson and Kevin Jones in the draft.
New York Giants (+9) at Philadelphia, 4:15, WTTG-5, WBFF-45
Is it such a great idea to start a quarterback (Kurt Warner) with two lead feet behind an offensive line that is the subject of many barbs? Coach Tom Coughlin will soon find out. Meanwhile, it has been reported that Eagles quarterback Donovan McNabb and new wide receiver Terrell Owens already have their touchdown celebrations planned out. "We have a list," McNabb told Sports Illustrated. Be afraid, be very afraid.
Atlanta (-31/2) at San Francisco, 4:15
New Falcons coach Jim Mora said he won't pull quarterback Michael Vick even if his performance is awful. "I absolutely will not pull Mike Vick," Mora said. "He could be 0 for 100, and he's going to throw pass number 101." Viewers may hear the words "Spin Off" a lot from the Niners' defense. That's the cue for defenders to abandon their men and find Vick should he scramble.
Kansas City (+3) at Denver, 8:30 p.m., ESPN
Chiefs running back Priest Holmes rushed for 48 touchdowns the last two seasons, an NFL record for consecutive years. The next best number from a running back over the past two years is Shaun Alexander's 30.
Green Bay (+3) at Carolina, 9 p.m. Monday, WJLA-7, WMAR-2
The Panthers have new starters at four positions on the offensive line, which may keep Jake Delhomme from becoming a big star, as many expect him to do. Meantime, new Packers defensive coordinator Bob Slowik has promised to blitz more than last season.