Detroit (+7) at Atlanta, 1
The Falcons are gunning for their first 5-0 start, while the Lions are looking to go 3-1 for the first time since 2000. Running back Artose Pinner will start for Detroit in place of the injured Kevin Jones. Atlanta's rush defense is second in the league at 62.8 yards per game.
New York Giants (+31/2) at Dallas, 1 (WTTG-5, WBFF-45)
The Giants are hoping things don't come down to the kicking game, because Steve Christie has made only 5 of 10 field goal attempts this season and missed all three last week against Green Bay. Trivial stat of the week: The Cowboys are 11-4 all-time after a bye week, second-best in NFL history.
Oakland (+9) at Indianapolis, 1
In his last start against Indianapolis (with the Giants in 2002), Oakland's Kerry Collins had a perfect passer rating of 158.3 and threw for 366 yards and four touchdowns. The Colts have the league's worst pass defense, allowing 313 yards per game.
Minnesota (-4) at Houston, 1
Minnesota defensive end Chris Hovan, who has started 47 straight games, was demoted to the second team, a move officially attributed to a bruised knee he suffered in practice Monday but unofficially attributed to his poor play of late. Hovan confronted Coach Mike Tice after practice on Wednesday. Trivial stat of the week, Part II: The Vikings have the league's all-time best record after a bye week (12-3).
Miami (+13) at New England, 1 (WUSA-9)
Bettors beware: Ten of the past 15 games in the series have been decided by seven points or less, and two of the past three have been decided in overtime. But that was then, and this is now, and the Dolphins have mustered just 237.8 yards per game, last in the league.
Cleveland (+6) at Pittsburgh, 1 (WJZ-13)
Pittsburgh's Jerome Bettis: 18 rushes, 22 yards, 5 touchdowns this season. Best stat line ever. Meantime, Duce Staley has yet to find the end zone despite averaging 93 yards per game. Ben Roethlisberger is the first Pittsburgh quarterback to win his first two starts since Mike Kruczek won his first nine in 1976.
Tampa Bay (+3) at New Orleans, 1
Looking for a spark, the Bucs (0-4) will start Chris Simms at quarterback in place of Brad Johnson, a move that produced some grumbles in the Tampa Bay locker room. The Saints are also far from a cohesive unit, as quarterback Aaron Brooks and defensive end Charles Grant got into a spat on the team plane after their loss to the Cardinals last week.
Buffalo (+7) at New York Jets, 4:05
Buffalo quarterback Drew Bledsoe and running back Travis Henry always have been strong against the Jets. Bledsoe has thrown for 4,163 yards in 20 games against New York, his second-most against any opponent. Henry has rushed for 567 yards and five touchdowns in five games against the Jets.
Jacksonville (-3) at San Diego, 4:05
After surrendering 122 yards rushing in each of the first two games, the Chargers have buckled down, holding the Broncos to 37 yards (Mike Shanahan's lowest total in 10 years as a head coach) in Week 3 and the Titans to 72 yards last week.
St. Louis (+7) at Seattle, 4:15 (WTTG-5, WBFF-45)
Seahawks defensive end Grant Wistrom faces his former team, whom he left as a free agent in the offseason after six productive seasons. With Wistrom, the Rams forced 46 takeaways last season; without him, they've forced a league-low two in four games this season. Seattle never has started 4-0 in team history.
Arizona (+11/2) at San Francisco, 4:15
The 49ers have 18 players on the injured list, including starting cornerback Mike Rumph (out at least eight weeks with a broken arm), starting defensive end Andre Carter (out three to five after having a cyst removed from his back) and starting linebacker Derek Smith (doubtful today with torn ankle ligaments).
Carolina (+51/2) at Denver, 4:15
Panthers running back Stephen Davis, who has missed the past two games after knee surgery, said only "a hurricane" could keep him out of the lineup today. He's listed as questionable and will be a game-time decision. In his stead, DeShaun Foster has rushed for 225 yards and two touchdowns.
Tennessee (+3) at Green Bay, 9 p.m. Tomorrow (WJLA-7, WMAR-2)
The Titans have allowed an NFL-worst 5.5 yards per carry and face Green Bay's Ahman Green, who is averaging 4.2 yards per carry. Green Bay wide receiver Javon Walker already has 376 receiving yards this season; his career high is 752, set last year.